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Virbac Animal Health, Effitix Plus Topical Solution for Dogs, 89 to 132 Lbs.-01/18/2016
Products in this Consumer Product Information Database (CPID) are classified based on their composition:
Substances: single chemicals
Preparations: products which contain chemicals that can be easily separated during normal use
Articles: products or product assemblies that do not contain chemicals that can be separated out from the product or assembly under normal or advertised use.
Classification: Preparation
Indicates country where product is sold.
Market: US/CanadaPurpose of product.
Usage: Flea and tick control for dogs.Structure such as solid, liquid, aerosol etc.
Form: liquidDate when validity of Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) was last verified.
Date verified: February 13, 20241301 Solana Boulevard, Suite 2400
Westlake TX 76262
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Chemical Composition/Ingredients
The GHS is an acronym for The Globally Harmonized System of Classification and Labelling of Chemicals. The GHS is a system for standardizing and harmonizing the classification and labelling of chemicals. Chemicals are associated with codes that define their health, physical and environmental hazards.This universal hazard communication system was developed to ensure that employers, employees and consumers are provided with adequate, practical, reliable and comprehensible information on the hazards of chemicals, so that they can take effective preventive and protective measure for their own health and safety.
Advanced
The GHS classifications for chemicals associated with products in this database may be viewed by selecting the "Advanced" button on the Chemical Ingredients tables. Since this is a work in progress, GHS classifications may not be shown for all chemical ingredients.-
Primary Chemical Name is the standard name assigned to a chemical substance.
ChemicalChemical Abstracts Service Registry Number is a unique identifier for a chemical and its synonyms. CAS numbers identify the chemical, but not its concentration or specific mixture. CAS Registry Numbers are assigned by the Chemical Abstracts Service, a division of the American Chemical Society. For more information: www.cas.org
CAS No./ID
We have assigned "ID numbers" (with 6 leading zeros or nines, e.g., 000000-xx-x , 888888-xx-x) or 999999-xx-x) for blends and chemicals that do not have CAS numbers.Percent of chemical in preparation.
% Conc.Chemical of Concern (CoC)
Chemical of Concern(CoC)Fipronil 120068-37-3 6.0 Yes 
CoC List
Permethrin 052645-53-1 44.8 Yes CoC List
Pyriproxyfen 095737-68-1 1.8 No Glycol ether(s) (unspecified) 000000-01-4 40.0-50.0 No -
Health Effects Information
Ingredients and Health Effects Information are taken from the manufacturer's product label and/or the Safety Data Sheet (SDS). Products are not tested and manufacturer's information presented here is not evaluated by DeLima Associates.
View Safety Data Sheet(SDS) Date that the Safety Data Sheet (SDS) was issued by manufacturer of a specific product.
SDS DATE :January 18, 2016 -
Warnings
Hazard Statements
Danger. Harmful if swallowed. Causes serious eye irritation. Causes damage to organs (central nervous system) (route of exposure: oral. Causes damage to organs (central nervous system) through prolonged or repeated exposure. Suspected of causing cancer. (route of exposure: oral). Very toxic to aquatic life.
Precautionary Statements
General
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood.
Prevention
Wash hands thoroughly after handling. Do not eat, drink, or smoke when using this product. Wear eye protection, face protection, protective clothing, and protective gloves. Do not breathe mist, vapors or spray. Avoid release to the environment.
Response
If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists, get medical advice/attention.
If exposed or concerned: Call a poison center or doctor. Get medical advice or attention if you feel unwell. Collect spillage.
Storage
Store locked up.
Disposal
Dispose of contents and container in accordance with local and national regulations. -
Acute health effects
From SDS:
Hazards Identification
Emergency Overview
Danger. Harmful if swallowed. Causes serious eye irritation. Causes damage to organs (central nervous system) (route of exposure: oral. Causes damage to organs (central nervous system) through prolonged or repeated exposure. Suspected of causing cancer. (route of exposure: oral). Very toxic to aquatic life.
Potential Health Effects
Eye Contact: Causes serious eye irritation.
Skin Contact: Mild or slight skin irritation
Ingestion: Harmful if swallowed -
Chronic health effects
From SDS:
Fipronil: In a 14 day repeat dose neurotoxicity study in dogs, the animals displayed neurotoxic signs which included hypoactivity, salivation, ataxia, convulsions, tremors, stiffened body, and muscle twitching. (UK-VMD)
Permethrin: 15-Day Inhalation Study in Rats LOAEL = 0.583 mg/l (converts to oral equivalent of 154 mg/kg/day) based on body tremors and hypersensitivity to noise. (EPA). A neurotoxicity study in rats showed dose-related responses. At doses greater than 1500 ppm animals displayed tremors, splayed hind legs and staggered gait. Deaths were observed at 4000 ppm. A NOAEL of 750 ppm was established. (UK-VMD)
Pyriproxyfen: No significant systemic toxicity was observed in either the 21-day dermal toxicity study in rats or the 28-day inhalation toxicity study in rats. Subchronic and chronic toxicity studies in mice, rats and dogs indicate that the liver and kidney are the principal target organs with slight anemia occurring in the rodent species. -
Carcinogenicity
Permethrin: EPA Classification: Likely to be Carcinogenic to Humans (by oral route) based on two reproducible benign tumor types (lung and liver) in the mouse, equivocal evidence of carcinogenicity in Long Evans rats, and supporting structural activity relationships (SAR) information.Fipronil: EPA: The carcinogenic potential of Fipronil has been classified as a Group C possible human carcinogen based on increases in thyroid follicular cell tumors in both sexes of the rat, which were statistically significant by both pair-wise and trend analyses. These results are thought to be due to a rodent specific liver effect not relevant to humans.Pyriproxyfen: There was no evidence of carcinogenicity in either a 78-week mouse feeding study or in the 2-year rat chronic/carcinogenicity study. Pyriproxyfen is classified as a “Group E” chemical - no evidence of carcinogenicity to humans. -
Handling information
Wear appropriate protective clothing. Wash hands thoroughly after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet. Store in tightly closed original container in a cool, dry, locked place. Keep away from children and pets. -
Disposal information
Dispose of in accordance with all applicable local and national regulations. -
First Aid
Eye Contact: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing the eye. Call a poison control center or doctor for treatment advice.Skin Contact: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice.Inhalation: Remove person to fresh air. Seek medical attention if symptoms persist.Ingestion: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything to an unconscious person.
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UN Global Harmonization Classification
